The Aim of the present investigation was to design and evaluate sustained release drug delivery system for Venlafaxine Hydrochloride with reduced frequency of drug administration, reduced side effects and improved patient compliance. Matrix tablets of Venlafaxine Hydrochloride were prepared using combination of various Hydrophobic and Hydrophilic polymers like Eudragit RS 100, EC 45 CPS, HPC EXF & HXF and HPMC K100M. All the precompressional parameter was found to be within the standard limit. No drug excipient incompatibility was seen. Venlafaxine Hydrochloride is an Antidepressant of the serotonin-nor epinephrine reuptake inhibitor (SNRI) After oral administration, Venlafaxine is completely absorbed from the gastrointestinal tract and undergoes extensive first pass metabolism and having low bioavailability (45%) with biological half life of 5hrs. Venlafaxine hydrochloride suitable candidate for developing matrix tablets. The matrix tablets of Venlafaxine hydrochloride were prepared by wet granulation method. The prepared tablets were evaluated for thickness, weight variation, friability, hardness and in vitro release of drug. All the physical characteristics of the fabricated tablets were found to within the acceptable limits. Among the formulations studied, first 5 formulations drug release was very fast and 90% of the drug was released in first 12 hrs only. Further batches were prepared and F9 containing HPMC K100M showed sustained release up to 24hrs and releases 99.31% of drug. Formulations containing HPC EXF, HPC HXF, Eudragit RS100 and EC 45 CPS could not efficiently retard the drug release up to 24hrs. The similarity factor (F2 value) of formulation F-9 was 77.38 and dissimilarity factor (F1 value) was 3.48. Successful development of the formulation fulfils the objective of the study. Hence formulation F9 was selected as the optimized formulation.
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